The Children's Brittle Bone Foundation would like to share with you information about the research we have funded (since April 1994).

OI - Treatment Challenge

(This award is $100,000/year for three years)

(3) Dr. Darwin J. Prockop, MD. Ph.D - Director Center For Gene Therapy MCP Hahnemann University, Philadelphia, PA. for  “Expansion of Stem cells from patients with OI for potential therapy of the Same patients”...2000-2002

(2) Dr. Barbara M. Brodsky from UMDNJ - Robert Wood Johnson Medical School in Piscataway, New Jersey for "Peptide Models of Collagen O.I. Mutation Sites: The Effect of Amino Acid Sequence On Triple Helix Properties and Clinical Phenotype"...1998-2000

(1) Dr. Richard J. Wenstrup from The Children's Hospital Research Foundation in Cincinnati, Ohio for the "Use Of Hammerhead Ribozymes In an Animal Model Of Osteogenesis Imperfecta"...1998-2000

Fellowship

(This award is $50,000/year for two years)

(12) Christopher B. Ballas Ph.D.:  Mentor Stanton L Gerson, MD Division of Hematology/Oncology Case Western Reserve School of Medicine.  Cleveland OH for “Transplantation Biology of Murine Bone Marrow Stroma”...2000-2002

(11) Christine D. Kulich, Ph.D.: Mentor Nelson Fausto.  Research Scientist Department of Pathology.  University of Washington School of Medicine, Seattle Washington for “The order of intron removal in type I collagen genes: the role of splice order on the outcome of splice site mutations.”...2000-2002

(10) Dr. David G. Stokes from Allegheny University of the Health Sciences in Philadelphia, Pennsylvania for the "Development of a Gene Therapy Strategy for OI and Characterization of Marrow Stromal Cells as the Therapeutic Vehicle"...1998-2000

(9) Dr. Robert Daniel Blank from The Hospital For Special Surgery in New York, New York working on "Modifiers of OIM: Mapping of Genes Affecting Bone Strength in Mice"...1998-2000

(8) Dr. Donna King from Finch University of Health Sciences/ The Chicago Medical school in Chicago, Illinois For "Gene Therapy To Reverse Bone Loss in OI"...1997-1999.

(7) Dr. Nancy P. Camacho from The Hospital for Special Surgery in New York, New York for the "Effect of a Third Generation Bisphosphonate on Bone Properties in the Growing OIM Mouse"...1996-1998.

(6) Dr. Jeanne Marie Boudreaux from the Washington University School Of Medicine in St. Louse, Missouri Working on "Fibroblast Growth Factor-Specific Transcriptional Regulation & The Molecular Biochemistry of Osteoblast Gene Expression"... 1996-19998

(5) Dr. Daniel McBride from John Hopkins University in Baltimore, Maryland Working on "Bone Marrow Transplantation in OIM Mice: A Tool To Study Somatic Gene Therapy"...1995-1997.

(4) Dr. Jerome Andre Rossert from The University of Texas, M.D. Anderson Cancer Center in Houston, Texas Working on the "Study of the Lineage - Specific Transcriptional Mechanisms Which Control Type I Collagen Synthesis in Osteoblasts"...1995-1997.

(3) Dr. Ruth Pereira from Hahnemann University Center for Gene Therapy in Philadelphia, Pennsylvania Working on "Transgenic Mouse Models Used to Explore Marrow Stromal Cell Therapy in the Treatment of Osteogenesis Imperfecta"...1995-1997.

(2) Dr. William Ross Wilcox from Cedar-Sinai Medical Center in Los Angeles, California Working on "collagen Stability in Osteogenesis Imperfecta"...1994-1996.

(1) Dr. Ming Qui from The University of Washington In Seattle, Washington for "The Identification and Characterization of Proteins that Bind Abnormal Type I Procollagen Molecules"... 1994-1996.

This research was selected from many applications submitted to The Children's Brittle Bone Foundation, following a study section review conducted by four to six researchers from related fields of study.

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